Hayakawa Y, Tamura S, Suzuki N, Odaira K, Tokoro M, Kawashima F, Hayakawa F, Takagi A, Katsumi A, Suzuki A, Okamoto S, Kanematsu T, Matsushita T, Kojima T. Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI. J Thromb Haemost. 2021 Apr;19(4):920-930.

 

Saito T, Hatta Y, Hayakawa F, Takahashi T, Hagihara M, Iida H, Minauchi K, Yamazaki E, Sugiura I, Murayama T, Sakura T, Mori N, Imai K, Yahagi Y, Atsuta Y, Saito AM, Hirakawa A, Kiyoi H, Matsumura I, Miyazaki Y; Japan Adult Leukemia Study Group. Combination of clofarabine, etoposide, and cyclophosphamide in adult relapsed/refractory acute lymphoblastic leukemia: a phase 1/2 dose-escalation study by the Japan Adult Leukemia Study Group. Int J Hematol. 2021 Mar;113(3):395-403.

 

Hatta Y, Hayakawa F, Yamazaki E. JSH practical guidelines for hematological malignancies, 2018: I. leukemia-3. acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). Int J Hematol. 2020 Oct;112(4):439-458.

 

Kanayama T, Imamura T, Mayumi A, Soma E, Sakamoto K, Hayakawa F, Tanizawa A, Kiyokawa N, Hosoi H. Functional analysis of a novel fusion protein PAX5-KIDINS220 identified in a pediatric Ph-like ALL patient. Int J Hematol. 2020 Nov;112(5):714-719.

 

Yoshikawa M, Takeichi T, Taki T, Hayakawa F, Ishii N, Hashimoto T, Muro Y, Akiyama M. A case of pemphigus with anti-desmoglein 3 and anti-desmocollin 2 and 3 autoantibodies, associated with follicular lymphoma and bronchiolitis obliterans. Eur J Dermatol. 2020 Aug 1;30(4):424-425.

 

Tokoro M, Tamura S, Suzuki N, Kakihara M, Hattori Y, Odaira K, Suzuki S, Takagi A, Katsumi A, Hayakawa F, Okamoto S, Suzuki A, Kanematsu T, Matsushita T, Kojima T. Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A. Mol Genet Genomic Med. 2020 Sep;8(9):e1390.

 

Inoue C, Sobue S, Mizutani N, Kawamoto Y, Nishizawa Y, Ichihara M, Takeuchi T, Hayakawa F, Suzuki M, Ito T, Nozawa Y, Murate T. Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes. Nagoya J Med Sci. 2020 May;82(2):261-280.

 

Akahane K, Yasuda T, Tsuzuki S, Hayakawa F, Kiyokawa N, Somazu S, Watanabe A, Kagami K, Abe M, Harama D, Goi K, Kawazu M, Kojima S, Imamura T, Goto H, Iwamoto S, Minegishi M, Abe M, Hojo H, Inaba T, Mano H, Sugita K, Inukai T. High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines. Hematol Oncol. 2020 Oct;38(4):614-617.

 

Tsuzuki S, Yasuda T, Kojima S, Kawazu M, Akahane K, Inukai T, Imaizumi M, Morishita T, Miyamura K, Ueno T, Karnan S, Ota A, Hyodo T, Konishi H, Sanada M, Nagai H, Horibe K, Tomita A, Suzuki K, Muramatsu H, Takahashi Y, Miyazaki Y, Matsumura I, Kiyoi H, Hosokawa Y, Mano H, Hayakawa F. Targeting MEF2D-fusion oncogenic transcriptional circuitries in B-cell precursor acute lymphoblastic leukemia  Blood Cancer Discovery. 2020 Jul; 1(1) 82 – 95.

 

Tange N, Hayakawa F, Yasuda T, Odaira K, Yamamoto H, Hirano D, Sakai T, Terakura S, Tsuzuki S, Kiyoi H. Staurosporine and venetoclax induce the caspase- dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells. Biomed Pharmacother. 2020 Aug;128:110330.

 

Inoue C, Sobue S, Kawamoto Y, Nishizawa Y, Ichihara M, Abe A, Hayakawa F, Suzuki M, Nozawa Y, Murate T. Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. Biochem Biophys Res Commun. 2020 May 14;525(4):1074-1080.

 

Ogawa M, Suzuki N, Takahashi N, Tamura S, Suzuki A, Suzuki S, Hattori Y, Kakihara M, Kanematsu T, Kojima T, Katsumi A, Hayakawa F, Kojima T, Ishiguro N, Kiyoi H, Matsushita T. Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy. Thromb Res. 2020 Apr;188:103-105.

 

Tsuzuki S, Yasuda T, Kojima S, et al. Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia. Blood Cancer Discovery. 2020; 1: 82.

 

Tokoro M, Tamura S, Suzuki N, et al. Aberrant X chromosomal rearrangement through multi-step template switching during sister chromatid formation in a patient with severe hemophilia A. Mol Genet Genomic Med. 2020; 8: e1390.

 

Tange N, Hayakawa F, Yasuda T, et al. Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells. Biomed Pharmacother. 2020; 128: 110330.

 

Ogawa M, Suzuki N, Takahashi N, et al. Higher FVIII:C measured by chromogenic substrate assay than by one-stage assay is associated with silent hemophilic arthropathy. Thromb Res. 2020; 188: 103.

 

Inoue C, Sobue S, Mizutani N, et al. Vaticanol C, a phytoalexin, induces apoptosis of leukemia and cancer cells by modulating expression of multiple sphingolipid metabolic enzymes. Nagoya J Med Sci. 2020; 82: 261.

 

Inoue C, Sobue S, Kawamoto Y, et al. Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells. Biochem Biophys Res Commun. 2020; 525: 1074.

 

Yamamoto H, Hayakawa F, Yasuda T, et al. ZNF384-fusion proteins have high affinity for the transcriptional　coactivator EP300 and aberrant transcriptional activities. FEBS Lett. 2019; 593: 2151.

 

Odaira K, Tamura S, Suzuki N, et al. Apparent synonymous mutation F9 c.87A>G causes secretion failure by in-frame mutation with aberrant splicing. Thromb Res. 2019; 179: 95.

 

Tamura S, Hashimoto E, Suzuki N, et al. Molecular basis of SERPINC1 mutations in Japanese patients with antithrombin deficiency. Thromb Res. 2019 Apr 11;178:159-170.

 

Hirano D, Hayakawa F, Yasuda T, et al. Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity. Oncogene. 2019 Mar;38(13):2263-2274.

 

Sakamoto A, Kunou S, Shimada K, et al. Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells. Cancer Sci. 2019 Jan;110(1):269-278.

 

Sakura T, Hayakawa F, Sugiura I, et al. High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG. Leukemia. 2018; 32: 626.

 

Li JF, Dai YT, Lilljebjörn H, et al. Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11711-E11720.

 

Shimada K, Hayakawa F, Kiyoi H. Biology and management of primary effusion lymphoma. Blood. 2018 Nov 1;132(18):1879-1888.

 

Inoue C, Sobue S, Aoyama Y, et al. BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells. Biochem Biophys Rep. 2018 Jul 13;15:69-75.

 

Hayakawa F. [Adult acute lymphoblastic leukemia: update on pathophysiology and management]. Rinsho Ketsueki. 2018;59(5):497-503. doi: 10.11406/rinketsu.59.497. Review. Japanese.

 

Yamaura T, Nakatani T, Uda K, et al. A novel irreversible FLT3 inhibitor, FF-10101, shows excellent efficacy against AML cells with FLT3 mutations. Blood. 2018; 131: 426.

 

Tanaka Y, Kawazu M, Yasuda T, et al. Transcriptional activities of DUX4 fusions in B-cell acute lymphoblastic leukemia. Haematologica. 2018 Nov;103(11):e522-e526.

 

Goto T, Murata M, Terakura S, et al. Phase I study of cord blood transplantation with intrabone marrow injection of mesenchymal stem cells: A clinical study protocol. Medicine (Baltimore). 2018 Apr;97(17):e0449.

 

Hatta Y, Mizuta S, Matsuo K, et al. Final analysis of the JALSG Ph+ALL202 study: tyrosine kinase inhibitor-combined chemotherapy for Ph+ALL. Ann Hematol. 2018 Sep;97(9):1535-1545.

早川 文彦 【急性白血病-最新の診断と治療-】急性白血病の分子病態　AYA世代急性白血病の分子病態. 2020.Mar. 日本臨床;78: 418-423

 

田村 彰吾, 高木 明, 早川 文彦, 小嶋 哲人　最近の血栓止血異常のとらえかた　検査室や研究室から　先天性凝固異常症の遺伝子解析　解析のStrategyとPitfall. 2020.Feb. 日本検査血液学会雑誌;21:71-81

悪性リンパ腫の腫瘍関連線維芽細胞由来のエクソソームはHDAC阻害剤耐性を誘導する　加賀谷 裕介, 島田 和之, 久納 俊祐, 疋田 智也, 坂本 明彦, 早川 文彦, 小根山 千歳, 清井 仁　第79回日本癌学会学術総会　2020.10. 口頭発表

 

Endothelial colony forming cells(ECFCs)樹立法の標準化への試み　岡本 修一, 鈴木 伸明, 兼松 毅, 鈴木 敦夫, 大平 晃也, 所 真昼, 早川 友梨, 田村 彰吾, 早川 文彦, 清井 仁, 小嶋 哲人, 松下 正　第42回日本血栓止血学会学術集会　2020.05. 口頭発表

 

Template switchingによるF8エクソン15欠損が認められた重症血友病A症例　所 真昼, 田村 彰吾, 鈴木 伸明, 大平 晃也, 河島 史華, 早川 友梨, 早川 文彦, 岡本 修一, 兼松 毅, 勝見 章, 松下 正, 小嶋 哲人　第42回日本血栓止血学会学術集会　2020.05. 口頭発表

 

当施設における新生児・乳幼児に対するエミシズマブの使用経験　兼松 毅, 鈴木 伸明, 岡本 修一, 鈴木 敦夫, 田村 彰吾, 早川 文彦, 小嶋 哲人, 清井 仁, 松下 正　第42回日本血栓止血学会学術集会　2020.05. 口頭発表

 

C末端伸長変異型Factor XIにおける分泌異常の解析　早川 友梨, 田村 彰吾, 鈴木 伸明, 大平 晃也, 所 真昼, 河島 史華, 早川 文彦, 高木 明, 鈴木 敦夫, 岡本 修一, 兼松 毅, 松下 正, 小嶋 哲人　第42回日本血栓止血学会学術集会　2020.05. 口頭発表

 

スプライシング異常を引き起こす血液凝固第IX因子遺伝子イントロン1内の深部大挿入変異　河島 史華, 田村 彰吾, 鈴木 伸明, 大平 晃也, 所 真昼, 早川 友梨, 早川 文彦, 岡本 修一, 兼松 毅, 高木 明, 松下 正, 小嶋 哲人　第42回日本血栓止血学会学術集会　2020.05. 口頭発表

 

Yoshida R, Seki S, Hasegawa J, Koyama T, Yamazaki K, Takagi A, Kojima T, Yoshimura M: Familial pulmonary thromboembolism with a prothrombin mutation and antithrombin resistance. J Cardiol Cases. 2018 Mar 27;17(6): 197–199.

 

Sanda N, Suzuki N, Suzuki A, Kanematsu T, Kishimoto M, Hasuwa H, Takagi A, Kojima T, Matsushita T, Nakamura S.: Vwf K1362A resulted in failure of protein synthesis in mice．Int J Hematol. 2018 Apr;107(4):428-435.

 

Tamura S, Suga Y, Tanamura M, Murata-Kawakami M, Takagi Y, Hattori Y, Kakihara M, Suzuki S, Takagi A, Kojima T: Optimisation of antithrombin resistance assay as a practical clinical laboratory test: development of prothrombin activator using factors Xa/Va and automation of assay. Int J Lab Hematol. 2018 Jun;40(3):312-319.

 

Sanda N, Suzuki N, Suzuki A, Kanematsu T, Kishimoto M, Hasuwa H, Takagi A, Kojima T, Matsushita T, Nakamura S. Vwf K1362A resulted in failure of protein synthesis in mice. Int J Hematol. 2018 Apr;107(4):428-435.

 

Tamura S, Suga Y, Tanamura M, Murata-Kawakami M, Takagi Y, Hattori Y, Kakihara M, Suzuki S, Takagi A, Kojima T. Optimisation of antithrombin resistance assay as a practical clinical laboratory test: Development of prothrombin activator using factors Xa/Va and automation of assay. Int J Lab Hematol. 2018 Jun;40(3):312-319.

 

Suzuki S, Nakamura Y, Suzuki N, Yamazaki T, Takagi Y, Tamura S, Takagi A, Kanematsu T, Matsushita T, Kojima T. Combined deficiency of factors V and VIII by chance coinheritance of parahaemophilia and haemophilia A, but not by mutations of either LMAN1 or MCFD2, in a Japanese family. Haemophilia. 24(1): e13-e16, 2018

 

Tamura S, Murata-Kawakami M, Takagi Y, Suzuki S, Katsumi A, Takagi A, Kojima T. In vitro exploration of latent prothrombin mutants conveying antithrombin resistance. Thromb Res. 159:33-38, 2017

 

Furuya F, Ishii T, Tamura S, Takahashi K, Kobayashi H, Ichijo M, Takizawa S, Kaneshige M, Suzuki-Inoue K, Kitamura K. The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-K B activities. Sci Rep. 7; 43960, 2017

 

Kamiyama M, Shirai T, Tamura S, Suzuki-Inoue K, Ehata S, Takahashi K, Miyazono K, Hayakawa Y, Sato T, Takeda K, Naguro I, Ichijo H. ASK1 facilitates tumor metastasis through phosphorylation of an ADP receptor P2Y12 in platelets. Cell Death Differ. 12:2066-2076, 2017

 

Yamashita A, Nagae C, Mori M, Ashikaga T, Kojima T, Taki M. First case report of hemophilia B Leyden in Japan. Int J Hematol. 106(1): 135-137, 2017

 

Miljic P, Gvozdenov M, Takagi Y, Takagi A, Pruner I, Dragojevic M, Tomic B, Bodrozic J, Kojima T, Radojkovic D, Djordjevic V. Clinical and biochemical characterization of the Prothrombin Belgrade mutation in a large Serbian pedigree: new insights into antithrombin resistance mechanism. J Thromb Haemost. 15(4):670-677, 2017

 

Moriyasu F, Furuichi Y, Tanaka A, Takikawa H, Yoshida H, Sakaida I, Obara K, Hashizume M, Kage M, Ohfuji S, Kitano S, Kawasaki S, Kokubu S, Matsutani S, Eguchi S, Shiomi S, Kojima T, Maehara Y, Kuniyoshi Y. Diagnosis and treatment guidelines for aberrant portal hemodynamics. Hepatol Res. 47(5):373-386, 2017

 

Takagi Y, Murata M, Kozuka T, Nakata Y, Hasebe R, Tamura S, Takagi A, Matsushita T, Saito H  Kojima T. Missense mutations in the gene encoding prothrombin corresponding to Arg596 cause antithrombin resistance and thrombomodulin resistance. Thromb Haemost. 116: 1022–31, 2016

 

Kozuka T, Tamura S, Kawamura N, Nakata Y, Hasebe R, Makiyama A, Takagi Y, Murata M, Mizutani N, Takagi A, Kojima T. Progestin isoforms provide different levels of protein S expression in HepG2 cells. Thromb Res. 145:40-45, 2016

 

Tamura S, Suzuki-Inoue K, Tsukiji N, Shirai T, Sasaki T, Osada M, Satoh K, Ozaki Y. Podoplanin-positive periarteriolar stromal cells promote megakaryocyte growth and proplatelet formation in mice by CLEC-2.Blood. 127(13):1701-10, 2016

 

Ozaki Y, Tamura S, Suzuki-Inoue K. New horizon in platelet function: with special reference to a recently-found molecule, CLEC-2. Thromb J. 14(Suppl 1): 27-36, 2016

 

Shirai T, Inoue O, Tamura S, Tsukiji N, Sasaki T, Endo H, Satoh K, Osada M, Sato-Uchida H, Fujii H, Ozaki Y, Suzuki-Inoue K. C-type lectin-like receptor 2 promotes hematogenous tumor metastasis and prothrombotic state in tumor-bearing mice. J Thromb Haemost.  38 (1): 42-49, 2016

 

Nakamura Y, Ando Y, Takagi Y, Murata M, Kozuka T, Nakata Y, Hasebe R, Takagi A, Matsushita T, Shima, M, Kojima T. Distinct X chromosomal rearrangements in four haemophilia B patients with entire F9 deletion. Haemophilia. 22(3):433-9, 2016

 

Kishimoto M, Suzuki N, Murata M, Ogawa M, Kanematsu T, Takagi A, Kiyoi H, Kojima T, Matsushita T. The first case of antithrombin-resistant prothrombin Belgrade mutation in Japanese. Ann Hematol. 2015  [Epub ahead of print]

 

Nakamura Y, Ando Y, Takagi Y, Murata M, Kozuka T, Nakata Y, Hasebe R, Takagi A, Matsushita T, Shima, M, Kojima T. Distinct X chromosomal rearrangements in four haemophilia B patients with entire F9 deletion. Haemophilia. 22(3), 433-9, 2016

 

Kovac M, Elezovic I, Mikovic Z, Mandic V, Djordjevic V, Radojkovic D, Lalic-Cosic S, Murata M, Takagi A, Kojima T. High prophylactic LMWH dose successfully suppressed hemostatic activation in pregnant woman with a new prothrombin c.1787G>A mutation. Thromb Res. 135(2):420-2, 2015

 

Yuasa D, Ohashi K, Shibata R, Mizutani N, Kataoka Y, Kambara T, Uemura Y, Matsuo K, Kanemura N, Hayakawa S, Miramatsu-Ito M, Ito M, Ogawa H, Murate T, Murohara T, Ouchi N. C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart. FASEB J. 30(3):1065-75, 2015

 

Mizutani N, Inoue M, Omori Y, Ito H, Tamiya-Koizumi K, Takagi A, Kojima T, Nakamura M, Iwaki S, Nakatochi M, Suzuki M, Nozawa Y, Murate T. Increased acid ceramidase expression depends on upregulation of androgen-dependent deubiquitinases, USP2, in a human prostate cancer cell line, LNCaP. J Biochem. 158(4), 309-19, 2015

 

Mizutani N, Omori Y, Tanaka K, Ito H, Takagi A, Kojima T, Nakatochi M, Ogiso H, Kawamoto Y, Nakamura M, Suzuki M, Kyogashima M, Tamiya-Koizumi K, Nozawa Y, Murate T. Increased SPHK2 transcription of human colon cancer cells in serum-depleted culture: the involvement of CREB transcription factor. J Cell Biochem. 116(10), 2227-38, 2015

 

Nakamura Y, Murata M, Takagi Y, Kozuka T, Nakata Y, Hasebe R, Takagi A, Kitazawa JI, Shima M, Kojima T. SVA retrotransposition in exon 6 of the coagulation factor IX gene causing severe hemophilia B. Int J Hematol. 102(1), 134-9, 2015

 

Takagi Y, Kato I, Ando Y, Nakamura Y, Murata M, Takagi A, Murate T, Kojima T. Antithrombin-resistant prothrombin Yukuhashi mutation also causes thrombomodulin resistance in fibrinogen clotting but not in protein C activation. Thromb Res. 134(4):914-7, 2014

 

Kato I, Takagi Y, Ando Y, Nakamura Y, Murata M, Takagi A, Murate T, Matsushita T, Nakashima T, Kojima T. A complex genomic abnormality found in a patient with antithrombin deficiency and autoimmune disease-like symptoms. Int J Hematol. 100(2):200-5, 2014

 

Murata M, Takagi A, Suzuki A, Okuyama E, Takagi Y, Ando Y, Kato I, Nakamura Y, Murate T, Matsushita T, Saito H, Kojima T. Development of a new laboratory test to evaluate antithrombin resistance in plasma. Thromb Res. 133(2):293-8, 2014

 

Okuyama E, Suzuki A, Murata M, Ando Y, Kato I, Takagi A, Murate T, Saito H, Kojima T. :Molecular mechanisms of syndecan-4 upregulation by TNF-α in the endothelium-like EAhy926 cells. J Biochem. 154(1):41-50, 2013

 

Suzuki A, Miyawaki Y, Okuyama E, Murata M, Ando Y, Kato I, Takagi Y, Takagi A, Murate T, Saito H, Kojima T.: Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor FVII gene expression. Biochem J. 449(1):231-9, 2013

 

Fujita J, Miyawaki Y, Suzuki A, Maki A, Okuyama E, Murata M, Takagi A, Murate T, Suzuki N, Matsushita T, Saito H, Kojima T.: A possible mechanisim for Inv22-related F8 large deletions in severe hemophilia A patients with high responding factor VIII inhibitors. J Thromb Haemost. 10(10): 2099-107, 2012

 

Miyawaki Y, Suzuki A, Fujita J, Maki A, Okuyama E, Murata M, Takagi A, Murate T, Kunishima S, Sakai M, Okamoto K, Matsushita T, Naoe T, Saito H, Kojima T.: Thrombosis  from a prothrombin mutation conveying antithrombin resistance. N Engl J Med. 366(25): 2390-6, 2012

 

Suzuki A, Nakashima D, Miyawaki Y, Fujita J, Maki A, Takagi A, Murate T, Teranishi M, Matsushita T, Saito H, Kojima T.: A novel ENG mutation causing impaired co-translational processing of endoglin associated with hereditary hemorrhagic telangiectasia. Thromb Res. 129(5): e200-8, 2012

 

Saito H, Matsushita T, Kojima T.: Historical perspective and future direction of coagulation research.  J Thromb Haemost. Suppl 1: 352-63, 2011.

 

Iwaki T, Tanaka A, Miyawaki Y, Suzuki A, Kobayashi T, Takamatsu J, Matsushita T, Umemura K, Urano T, Kojima T, Terao T, Kanayama N.: Life-threatening hemorrhage and prolonged wound healing are remarkable phenotypes manifested by complete plasminogen activator inhibitor-1 deficiency in humans. J Thromb Haemost. 9(6): 1200-6, 2011.

 

Ikesue M, Matsui Y, Ohta D, Danzaki K, Ito K, Kanayama M, Kurotaki D, Morimoto J, Kojima T, Tsutsui H, Uede T.: Syndecan-4 deficiency limits neointimal formation after vascular injury by regulating vascular smooth muscle cell proliferation and vascular progenitor cell mobilization. Arterioscler Thromb Vasc Biol. 31(5): 1066-74, 2011.

 

Matsui Y, Ikesue M, Danzaki K, Morimoto J, Sato M, Tanaka S, Kojima T, Tsutsui H, Uede T.: Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarction. Circ Res. 108(11): 1328-39, 2011.

 

Katsumi A, Nishida T, Murata M, Terakura S, Shimada K, Saito S, Kobayashi M, Kodaira A, Shibata S, Oda I, Yagi T, Kiyoi H, Matsushita T, Kojima T, Naoe T.: Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. J Clin Exp Hematop. 51(1): 63-5, 2011.

 

Katsumi A, Kiyoi H, Abe A, Tanizaki R, Iwasaki T, Kobayashi M, Matsushita T, Kaibuchi K, Senga T, Kojima T, Kohno T, Hamaguchi M, Naoe T.: FLT3/ITD regulates leukaemia cell adhesion through α4β1 integrin and Pyk2 signaling. Eur J Haematol. 86(3): 191-198, 2011.

 

Miyawaki Y, Suzuki A, Fujimori Y, Takagi A, Murate T, Suzuki N, Katsumi A, Naoe T, Yamamoto K, Matsushita T, Takamatsu J, Kojima T.: Severe hemophilia A in a Japanese female caused by an F8-intron 22 inversion associated with skewed X chromosome inactivation. Int J Hematol. 92(2): 405-408, 2010.

 

Okada H, Toyoda Y, Takagi A, Saito H, Kojima T, Yamazaki T.: Activated protein C resistance in the Japanese population due to homozygosity for the factor V R2 haplotype. Int J Hematol. 91(3): 549-550, 2010.

 

Okada H, Kunishima S, Hamaguchi M, Takagi A, Yamamoto K, Takamatsu J, Matsushita T, Saito H, Kojima T, Yamazaki T.: A novel splice site mutation in intron C of PROS1 leads to markedly reduced mutant mRNA level, absence of thrombin-sensitive region, and impaired secretion and cofactor activity of mutant protein S. Thromb Res.125(5): e246-e250, 2010.

 

Suzuki A, Sanda N, Miyawaki Y, Fujimori Y, Yamada T, Takagi A, Murate T, Saito H, Kojima T.: Down-regulation of PROS1 gene expression by 17β-estradiol via estrogen receptor α (ERα)-Sp1 interaction recruiting receptor-interacting protein140 and the corepressor-HDAC3 complex. J Biol Chem. 285(18): 13444-13453, 2010.

 

Tanaka R, Nakashima D, Suzuki A, Miyawaki Y, Fujimori Y, Yamada T, Takagi A, Murate T, Yamamoto K, Katsumi A, Matsushita T, Naoe T, Kojima T.: Impaired secretion of carboxyl-terminal truncated factor VII due to an F7 nonsense mutation associated with FVII deficiency. Thromb Res. 2010 Mar;125(3):262-6, 2010.

 

Yamada T, Fujimori Y, Suzuki A, Miyawaki Y, Takagi A, Murate T, Sano M, Matsushita T, Saito H, Kojima T.: A novel missense mutation causing abnormal LMAN1 in a Japanese patient with combined deficiency of factor V and factor VIII. Am J Hematol. 84(11): 738-742. 2009

 

Yamamoto K, Shibayama S, Takeshita K, Kojima T, Takamatsu J.: A novel cholesterol absorption inhibitor, ezetimibe, decreases adipose-derived and vascular PAI-1 expression in vivo. Thromb Res. 124(5): 644-645. 2009.

 

Takagi A, Tanaka R, Nakashima D, Fujimori Y, Yamada T, Okumura K, Murate T, Yamada M, Horikoshi Y, Yamamoto K, Katsumi A, Matsushita T, Naoe T, Kojima T.: Definite diagnosis in Japanese patients with protein C deficiency by identification of causative PROC mutations. Int J Hematol. 89(4): 555-557, 2009.

 

Yamamoto K, Takeshita K, Kojima T, Takamatsu J.: Stress-induced PAI-1 expression is suppressed by pitavastatin in vivo. Int J Hematol. 89(4), 553-554, 2009 May.

 

Miyata T, Sato Y, Ishikawa J, Okada H, Takeshita S, Sakata T, Kokame K, Kimura R, Honda S, Kawasaki T, Suehisa E, Tsuji H, Madoiwa S, Sakata Y, Kojima T, Murata M, Ikeda Y.: Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis. Thromb Res. 124(1): 14-18, 2009.

 

Ishikawa J, Okada H, Kato H, Takeshita S, Honda S, Kawasaki T, Suehisa E, Tsuji H, Madoiwa S, Sakata Y, Kojima T, Murata M, Ikeda Y, Kokubo Y, Okamura T, Tomoike H, Miyata T.: Association of Asn221Ser mutation in tissue factor pathway inhibitor-[beta] with plasma total tissue factor pathway inhibitor level. Blood Coagulation & Fibrinolysis. 20(1): 22-26, 2009.

 

Iwasaki T, Katsumi A, Kiyoi H, Tanizaki R, Ishikawa Y, Ozeki K, Kobayashi M, Abe A, Matsushita T, Watanabe T, Amano M, Kojima T, Kaibuchi K, Naoe T.: Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. Eur J Haematol. 81(6): 454-60, 2008.

 

Tanizaki R, Katsumi A, Kiyoi H, Kunishima S, Iwasaki T, Ishikawa Y, Kobayashi M, Abe A, Matsushita T, Watanabe T, Kojima T, Kaibuchi K, Kojima S, Naoe T.: Mutational analysis of SOS1 in acute myeloid leukemia. Int J Hematol. 88(4): 460-2, 2008.

 

Fujimori Y, Okimatsu H, Kashiwagi T, Sanda N, Okumura K, Takagi A, Nagata K, Murate T, Uchida A, Node K, Saito H, Kojima T.: Molecular Defects Associated with Antithrombin Deficiency and Dilated Cardiomyopathy in a Japanese Patient. Inter Med. 47(10): 925-931, 2008.

 

Ozlu F, Kyotani M, Taskin E, Ozcan K, Kojima T, Matsushita T, Yapicioğlu H, Takagi A, Saşmaz I, Satar M, Narli N.: A neonate with homozygous protein C deficiency with a homozygous Arg178Trp mutation. J Pediatr Hematol Oncol. 30(8): 608-611, 2008

 

Okumura K, Fujimori Y, Takagi A, Murate T, Ozeki M, Yamamoto K, Katsumi A, Matsushita T, Naoe T, Kojima T.: Skewed X chromosome inactivation in fraternal female twins results in moderately severe and mild haemophilia B. Haemophilia. 14(5), 1088-1093, 2008.

 

Nakayama T, Matsushita T, Yamamoto K, Mutsuga N, Kojima T, Katsumi A, Nakao N, Sadler JE, Naoe T, Saito H.: Identification of amino acid residues responsible for von Willebrand factor binding to sulfatide by charged-to-alanine-scanning mutagenesis. Int J Hematol, 87(4): 363-370, 2008.

 

Kashiwagi T, Matsushita T, Ito Y, Hirashima K, Sanda N, Fujimori Y, Yamada T, Okumura K, Takagi A, Murate T, Katsumi A, Takamatsu J, Yamamoto K, Naoe T, Kojima T.: L1503R is a member of group I mutation and has dominant-negative effect on secretion of full-length VWF multimers: an analysis of two patients with type 2A von Willebrand disease.  Haemophilia. 14(3), 556-563, 2008.

 

Kojima T, Saito H.: Hypercoagulable States. K. Tanaka, and E.W. Davie, eds; Recent Advances in Thrombosis and Hemostasis 2008. pp.507-520, Springer, printed in Japan, 2008.

 

Kon S, Ikesue M, Kimura C, Aoki M, Nakayama Y, Saito Y, Kurotaki D, Diao H, Matsui Y, Segawa T, Maeda M, Kojima T, Uede T.: Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin. J Exp Med. 205(1): 25-33, 2008

 

Yin T, Takeshita S, Sato Y, Sakata T, Shin Y, Honda S, Kawasaki T, Tsuji H, Kojima T, Madoiwa S, Sakata Y, Murata M, Ikeda Y, Miyata T.: A large deletion of the PROS1 gene in a deep vein thrombosis patient with protein S deficiency.  Thromb Haemost. 98(4): 783-789. 2007.

 

Sanda N, Fujimori Y, Kashiwagi T, Takagi A, Murate T, Mizutani E, Matsushita T, Naoe T, Kojima T.: An Sp1 binding site mutation of the PROS1 promoter in a patient with protein S deficiency.  Br J Haematol. 138(5): 663-665, 2007.

 

Kyotani M, Okumura K, Takagi A, Murate T, Yamamoto K, Matsushita T, Sugimura M, Kanayama N, Kobayashi T, Saito H, Kojima T.: Molecular basis of antithrombin deficiency in four Japanese patients with antithrombin gene abnormalities including two novel mutations.  Am J Hematol. 82(8): 702-705, 2007.

 

Yamamoto K, Kojima T, Takeshita K, Matsushita T, Takamatsu J.: Pitavastatin attenuates the upregulation of tissue factor in restraint-stressed mice. Thromb Res. 120(1):143-144, 2007.

 

Muramatsu T, Muramatsu H, Kojima T.: Identification of proteoglycan-binding proteins.  Methods Enzymol. 416: 263-278, 2006.

 

Yanada M, Matsushita T, Suzuki M, Kiyoi H, Yamamoto K, Kinoshita T, Kojima T, Saito H, Naoe T.: Disseminated intravascular coagulation in acute leukemia: clinical and laboratory features at presentation.  Eur J Haematol, 77(4): 282-287, 2006.

 

Okada H, Yamazaki T, Takagi A, Murate T, Yamamoto K, Takamatsu J, Matsushita T, Naoe T, Kunishima S, Hamaguchi M, Saito H, Kojima T.: In vitro characterization of missense mutations associated with quantitative protein S deficiency.  J Thromb Haemost. 4(9): 2003-2009, 2006.

 

Kuwana M, Kurata Y, Fujimura K, Fujisawa K, Wada H, Nagasawa T, Nomura S, Kojima T, Yagi H, Ikeda Y.: Preliminary laboratory-based diagnostic criteria for immune thrombocytopenic purpura: Evaluation by multi-center prospective study.  J Thromb Haemost. 4(9): 1936-1943, 2006.

 

Katsumi A, Matsushita T, Hirashima K, Iwasaki T, Adachi T, Yamamoto K, Kojima T, Takamatsu J, Saito H, Naoe T.: Recurrent intramural hematoma of small intestine in a severe hemophilia A patient with high titer of factor VIII inhibitor. A case report and a review of the literatures.  Int J Hematol. 84(2): 166-169, 2006.

 

Okumura K, Kyotani M, Kawai R, Takagi A, Murate T, Yamamoto K, Takamatsu J, Matsushita T, Saito H, Kojima T.: Recurrent mutations of factor XI gene in Japanese.  Int J Hematol. 83(5): 462-463, 2006.

 

Matsushita T, Adachi H, Watanabe H, Shimoyama Y, Adachi T, Sobue G, Ito M, Kojima T, Saito H, Naoe T.: Classic Polyarteritis Nodosa Presenting Rare Clinical Manifestations in a Patient with Hemophilia A.  Int J Hematol. 83(5): 420-425, 2006.

 

Adachi T, Matsushita T, Ichihashi R, Hirashima K, Ito M, Inukai A, Yokozawa T, Nishida T, Murata M, Hayashi M, Katsumi A, Kojima T, Saito H, Naoe T.: High Titer of ADAMTS13 Inhibitor Associated with Thrombotic Microangiopathy of the Gut and Skeletal Muscle after Allogenic Hematopoietic Stem Cell Transplantation.  Int J Hematol. 83(5): 415-419, 2006.

 

Yamakage N, Ikejiri M, Okumura K, Takagi A, Murate T, Matushita T, Naoe T, Yamamoto K, Takamatsu J, Yamazaki T, Hamaguchi M, Kojima T.: A case of coagulation factor V deficiency caused by compound heterozygous mutations in the factor V gene. Haemophilia. 12(2): 172-178, 2006.

 

Kimura R, Honda S, Kawasaki T, Tsuji H, Madoiwa S, Sakata Y, Kojima T, Murata M, Nishigami K, Chiku M, Hayashi T, Kokubo Y, Okayama A, Tomoike H, Ikeda Y, Miyata T.: Protein S K196E mutation as a genetic risk for deep vein thrombosis in Japanese patients.  Blood. 107(4): 1737-1738, 2006.

 

Kunishima S, Motoyama M, Takagi A, Hamaguchi M, Kojima T, Saito H.: Further characterization of anti-platelet monocl Yamamoto K, Honda T, Matsushita T, Kojima T, Takamatsu J.: Anti-HCV agent, ribavirin, elevates the activity of clotting factor VII in hemophilia patients: a possible mechanism of decreased events of bleeding in hemophiliacs by ribavirin.  J Thromb Haemost. 4(2):469-70, 2006.

 

Yamamoto K, Honda T, Matsushita T, Kojima T, Takamatsu J.: Anti-HCV agent, ribavirin, elevates the activity of clotting factor VII in hemophilia patients: a possible mechanism of decreased events of bleeding in hemophiliacs by ribavirin.  J Thromb Haemost. 4(2):469-70, 2006.

 

Hayashi M, Matsushita T, Mackman N, Ito M, Adachi T, Katsumi A, Yamamoto K, Takeshita K, Kojima T, Saito H, Murohara T, Naoe T.: Fatal thrombosis of antithrombin deficient mice is rescued differently in the heart and liver by intercrossing with low tissue factor mice.  J Thromb Haemost. 4(1):177-85, 2006.

 

Adachi T, Matsushita T, Dong Z, Katsumi A, Nakayama T, Kojima T, Saito H, Sadler JE, Naoe T.: Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor.  Biochem Biophys Res Commun. 339(4): 1178-83, 2006.

 

Saito H, Matsushita T, Yamamoto K, Kojima T, Kunishima S.: Giant platelet syndrome.  Hematology. 10 Suppl 1:41-46, 2005.

 

Yamamoto K, Kojima T, Adachi T, Hayashi M, Matsushita T, Takamatsu J, Loskutoff DJ, Saito H.: Obesity enhances the induction of plasminogen activator inhibitor-1 by restraint stress: a possible mechanism of stress-induced renal fibrin deposition in obese mice.  J Thromb Haemost. 3(7): 1495-1502, 2005.

 

Yamamoto K, Takeshita K, Kojima T, Takamatsu J, Saito H.: Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly.  Cardiovas Res. 66(2): 276-285, 2005.

 

Matsushita T, Hayashi H, Kunishima S, Hayashi M, Ikejiri M, Takeshita K, Yuzawa Y, Adachi T, Hirashima K, Sone M, Yamamoto K, Takagi A, Katsumi A, Kawai K, Nezu T, Takahashi M, Nakashima T, Naoe T, Kojima T, Saito H.: Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: Hematological, nephrological, and otological studies of heterozygous KO mice. Biochem Biophys Res Commn. 325 (4): 1163-1171, 2004.

 

Okada H, Takagi A, Murate T, Adachi T, Yamamoto K, Matsushita T, Takamatsu J, Sugita K, Sugimoto M, Yoshioka A, Yamazaki T, Saito H, Kojima T.: Identification of protein S gene mutations including four novel mutations in eight unrelated patients with protein S deficiency. Br J Haematol. 126 (2): 219-225, 2004.

 

Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R.: Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates.  Proc Natl Acad Sci, USA. 101 (21), 8132-8137, 2004.

 

Shimizu A, Matsushita T, Kondo T, Inden Y, Kojima T, Saito H, Hirai M.: Identification of the Amino Acid Residues of the Platelet Glycoprotein Ib (GPIb) Essential for the von Willebrand Factor Binding by Clustered Charged-to-Alanine Scanning Mutagenesis.  J Biol Chem. 279 (16): 16285-16294, 2004.

 

Takeshita K, Hayashi M, Iino S, Kondo T, Inden Y, Iwase M, Kojima T, Hirai M, Ito M, Loskutoff DJ, Saito H, Murohara T, Yamamoto K.: Increased Expression of Plasminogen Activator Inhibitor-1 in Cardiomyocytes Contributes to Cardiac Fibrosis after Myocardial Infarction. Am J Pathol. 164 (2): 449-456, 2004.

 

Yamada T, Takagi A, Takeshita K, Yamamoto K, Ito M, Matsushita T, Murate T, Saito H, Kojima T.: Enzyme immunoassay for measurement of murine plasminogen activator inhibitor-1, employing a specific antibody produced by the DNA vaccine method.  Thromb Res. 111 (12): 285-291, 2003.

 

Tsukahara A, Yamada T, Takagi A, Murate T, Matsushita T, Saito H, Kojima T.: Compound heterozygosity for two novel mutations in a severe factor XI deficiency.  Am J Hematol. 73 (4): 279-284, 2003.

 

Kunishima S, Kojima T, Inoue C, Kamiya T, Saito H.: GATA-1 transcription factor is mutated in CMK megakaryoblastic cell line. Br J Haematol. 120 (3): 542-543, 2003.

 

Kunishima S, Matsushita T, Kojima T, Sako M, Kimura F, Jo EK, Inoue C, Kamiya T, Saito H.: Immuno-fluorescence analysis of neutrophil nonmuscle myosin heavy chain-A (NMMHCA) in MYH9 disorders: association of subcellular localization with MYH9 mutations.  Lab Invest. 83 (1): 115-122, 2003.

 

Ishiguro K, Kojima T, Muramatsu T.: Syndecan-4 as a molecule involved in defense mechanisms.  Glycoconjugate J. 19 (4-5): 315-318, 2002.

 

Takeshita K, Yamamoto K, Ito M, Kondo T, Matsushita T, Hirai M, Kojima T, Nishimura M, Nabeshima Y, Loskutoff DJ, Saito H, Murohara T.: Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, “klotho” mouse. Semin Thromb Hemost. 28 (6): 545-553, 2002.

 

Yamamoto K, Shimokawa T, Yi H, Isobe K, Kojima T, Loskutoff DJ, Saito H.: Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse.  Blood. 100 (12): 4011-4018, 2002.

 

Yamamoto K, Shimokawa T, Yi H, Isobe K, Kojima T, Loskutoff DJ, Saito H.: Aging accelerates endotoxin-induced thrombosis: increased responses of plasminogen activator inhibitor-1 and LPS signaling with aging.  Am J Pathol. 161 (5): 1805-1814, 2002.

 

Ishiguro K, Muramatsu T, and Kojima T.: Syndecan-4 (Ryudocan) as a Defence molecule in Endotoxin Shock.  Connective Tissue. 34 (3): 277-282, 2002.

 

Kojima T.: Targeted gene disruption of natural anticoagulant proteins in mice.  Int J Hematol. 76 (Suppl. 2): 36-39, 2002.

 

Nakayama T, Matsushita T, Dong Z, Sadler JE, Jorieux S, Mazurier C, Meyer D, Kojima T, Saito H.: Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by Cys509-Cys695 disulfide bond.  J Biol Chem. 277 (24): 22063-22072, 2002.

 

Yanada M, Kojima T, Ishiguro K, Nakayama Y, Yamamoto K, Matsushita T, Kadomatsu K, Nishimura M, Muramatsu T, Saito H.: The impact of antithrombin deficiency in thrombogenesis: LPS and stress-induced thrombus formation in heterozygous antithrombin deficient mice.  Blood. 99 (7): 2455-2458, 2002.

 

Kunishima S, Matsushita T, Kojima T, Amemiya N, Choi YM, Hosaka N, Inoue M, Jung Y, Mamiya S, Matsumoto K, Miyajima Y, Zhang G, Ruan C, Saito K, Song KS, Yoon HJ, Kamiya T, Saito H.: Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions. J Hum Genet. 46:722-729, 2001.

 

Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Iwase M, Yoshikai Y, Yanada M, Yamamoto K, Matsushita T, Nishimura M, Kusugami K, Saito H, Muramatsu T.: Syndecan-4 deficiency leads to high mortality of lipopolysaccharide-injected mice.  J Biol Chem. 276 (50): 47483-47488, 2001.

 

Shirahata A, Kamiya T, Takamatsu J, Kojima T, Fukutake K, Arai M, Hanabusa H, Tagami H, Yoshioka A, Shima GM, Naka GH, Fujita GS, Minamoto Y, Kamizono J, Saito H.: Clinical trial to investigate the pharmacokinetics, pharmacodynamics, safety, and efficacy of recombinant factor VIIa in Japanese patients with hemophilia with inhibitors.  Int J Hematol. 73 (4): 517-525, 2001.

 

Shimokawa T, Yamamoto K, Yamafuji E, Kojima T, Saito H.: Expression of Protein S in the Murine Heart and Cultured Mouse Cardiomyocytes, Is Down-regulated by Cytokines. Thromb Haemost. 86 (2): 623–629, 2001.

 

Iwaki T, Mastushita T, Kobayashi T, Yamamoto Y, Nomura Y, Kagami K, Nakayama T, Sugiura I, Kojima T, Takamatsu J, Kanayama N, Saito H.: DNA sequence analysis of protein S deficiency--identification of four point mutations in twelve Japanese subjects.  Semin Thromb Hemost. 27(2): 155-60, 2001.

 

Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Matsuo S, Kusugami K, Saito H, Muramatsu T.: Syndecan-4 Deficiency Increase Susceptability to k-Carrageenan-Induced Renal Damage.  Lab Invest. 81 (4), 509-516, 2001.

 

Kojima T, Takagi A, Maeda M, Segawa T, Shimizu A, Yamamoto K, Matsushita T, Saito H.: Plasma Levels of Syndecan-4 (Ryudocan) Are Elevated in Patients with Acute Myocardial Infarction.  Thromb Haemost. 85 (5): 793–799, 2001.

 

Kunishima S, Kojima T, Matsushita T, Tanaka T, Tsurusawa M, Furukawa Y, Nakamura Y, Okamura T, Amemiya N, Nakayama T, Kamiya T, Saito H.: Mutations in the NMMHC-A gene cause autosomal dominant macrothrombocyto-penia with leukocyte inclusions (May-Hegglin anomaly/Sebastian syndrome).  Blood. 97 (4): 1147-1149, 2001.

 

Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Nakamura E, Ito M, Nagasaka T, Kobayashi H, Kusugami K, Saito H, Muramatsu T.: Syndecan-4 deficiency impairs the fetal vessels in the placental labyrinth.  Dev Dyn. 219(4):539-44, 2000.

 

Sakata M, Kobayashi H, Sun GW, Mochizuki O, Takagi A, Kojima T.: Ryudocan expression by lueinized granulosa cells is associated with the process of follicle atresia.  Fertil Steril. 74 (6): 1208-1214, 2000.

 

Shimokawa T, Yamamoto K, Kojima T, Saito H.: Down-regulation of murine tissue factor pathway inhibitor mRNA by endotoxin and tumor necrosis factor-αin vitro and in vivo.  Thromb Res. 100 (3): 211-221, 2000.

 

Nakayama Y, Kojima T, Takagi A, Yanada M, Yamamoto K, Matsushita T, Saito H.: Cloning and Characterization of the Murine Antithrombin Gene.  Thromb Res. 100 (3): 179-183, 2000.

 

Ishiguro K, Kojima T, Kadomatsu K, Nakayama Y, Takagi A, Suzuki M, Takeda N, Ito M, Yamamoto K, Matsushita T, Kusugami K, Muramatsu T, Saito H.: Complete antithrombin deficiency in mice results in embryonic lethality.  J Clin Invest. 106 (7): 873-878, 2000.

 

Takahashi I, Kojima T, Sano M, Watanabe T, Kamiya T, Saito H.: Detailed characterization of an anti-factor IX monoclonal antibody that neutralizes the prolonged ox brain prothrombin time of hemophilia BM by synthetic peptides.  Peptides. 21 (5): 603-753, 2000.

 

Iba K, Albrechtsen R, Gilpin B, Fröhlich C, Loechel F, Zolkiewska A, Ishiguro K, Kojima T, Liu W, Langford JK, Sanderson RD, Brakebusch C, Fässler R, Wewer UM. The cysteine-rich domain of human ADAM12 supports cell adhesion through syndecans and triggers signaling events that leads to β1-dependent cell spreading.  J Cell Biol. 149 (5): 1143-1155, 2000.

 

Sugihara T, Takahashi I, Kojima T, Okamoto Y, Yamamoto K, Kamiya T, Matsushita T, Saito H.: Identification of plasma antibody epitopes and gene abnormalities in Japanese hemophilia A patients with factor VIII inhibitor.  Nagoya J Med Sci. 63 (1): 25-39, 2000.

 

Kojima T.: Molecular biology of ryudocan, a endotherial heparan sulfate proteoglycan. Seminar in Thromb Hemost. 26 (1): 67-73, 2000.

 

Nakayama T, Matsushita T, Hidano H, Suzuki C, Hamaguchi M, Kojima T, Saito H.: Short report: A case of purpura fulminans is caused by homozygous delta8857 mutation (protein C-nagoya) and successfully treated with activated protein C concentrate.  Br J Haematol. 110 (3): 727-30, 2000.

 

Ishiguro K, Kadomatsu K, Kojima T, Muramatsu H, Tsuzuki S, Nakamura E, Kusugami K, Saito H, Muramatsu T.: Syndecan-4 Deficiency Impairs Focal Adhesion Formation Only under Restricted Conditions.  J Biol Chem. 275 (8), 5249-5252, 2000.

Katsumi A, Matsushita T, Yamazaki T, Sugiura I, Kojima T, Saito H.: Severe Factor VII Deficiency Caused by a Novel Mutation His348 to Gln in the Catalytic Domain. Thromb Haemost. 83 (2): 239-243, 2000.

小嶋哲人：プロテインC、プロテインS　　ベッドサイド検査事典　『腎と透析』編集委員会：編　腎と透析　Vol 84 2018増刊号 231-2333, 2018.5.30

 

小嶋哲人：5章 血栓性疾患02アンチトロンビンレジスタンス（ATR）　臨床に直結する血栓止血学 改定2版　朝倉英策編　中外医学社 東京pp432-437, 2018.10.20.

 

小嶋哲人：6章 抗血栓療法02ワルファリン　臨床に直結する血栓止血学 改定2版　朝倉英策編　中外医学社 東京pp532-536, 2018.10.20.

 

小嶋哲人：IX 治療薬ヘパリン類似物質　徹底ガイドDICのすべて　丸藤哲編　救急・集中治療臨時増刊号　総合医学社 東京pp354-359, 2018.11.20.

 

高木夕希、小嶋哲人：アンチトロンビンレジスタンス．Coagulation & Inflamation, 3(1):27-31, 2017

 

小嶋哲人：血栓止血学のトピックス．Cardio-Coagulation. 4(2):5831, 2017

 

田村彰吾、井上克枝、小嶋哲人：2．巨核球造血の微小環境．血液フロンティア．27(6):37-46, 2017

 

田村彰吾、尾崎由基男、小嶋哲人、井上克枝： 血小板・巨核球造血微小環境を構成する骨髄間質細胞. 日本血栓止血学会誌 28 (1), 59-63, 2017

 

高木夕希, 小嶋哲人：Annual Review 2016 血液・血液凝接触相ー最近の進歩ー. 中外医学社，中山書店　212-217, 2016

 

高木夕希, 小嶋哲人：科学評論社　循環器内科 Cardioangiology. 79(1): 60-64, 2016

 

小嶋哲人、高木明、村田萌、髙木夕希：新たな血栓性素因：アンチトロンビン・レジスタンス　日本産婦人科・新生児血液学会誌 25(2), 65-72, 2016.

 

村田萌：アンチトロンビンレジスタンス検出検査法の開発　血栓止血誌　26(4), 439-444, 2015.

 

小嶋哲人、高木明、村田萌、高木夕希：アンチトロンビンレジスタンスー新しい遺伝性血栓生素因ー　臨床血液 56(6), 632-638, 2015.

 

村田萌、小嶋哲人：プロテインC、プロテインS　これだけは知っておきたい検査のポイント 第9集『medicina』

 

高木夕希、小嶋哲人：アンチトロンビン　これだけは知っておきたい検査のポイント 第9集『medicina』

 

村田萌、小嶋哲人：EBM 血液疾患の治療 2015-2016

 

高木夕希、小嶋哲人：凝固阻止因子欠乏症／異常症　よくわかる 血栓・止血異常の診療

 

高木夕希、小嶋哲人：先天性アンチトロンビン欠乏症と先天性アントロンビン抵抗性　血液フロンティア 25(1), 2015.

 

村田萌、小嶋哲人：INTERFACE アンチトロンビンレジスタンス International Review of Thrombosis 8(4), 2013.

 

村田萌、小嶋哲人：臨床雑誌　内科　検査値を読む2013　プロテインC，プロテインS、アンチトロンビン　111(6), 2013.

 

髙木夕希、小嶋哲人：先天性血栓形成性疾患　活性化プロテインC(APC)レジスタンス　日本臨床　新領域別症候群シリーズ　No.23 27-30, 2013.

 

小嶋哲人：新規血栓性素因・アンチトロンビン抵抗性遺伝子異常　日本血栓止血学会誌　24(1), 53-55, 2013.

 

村田萌、小嶋哲人：I. 基礎　3）血友病Bの分子生物学　血友病の基礎と臨床　改訂版　白幡聡編　医ジャーナル社 東京pp51-56, 2012.

 

奥山恵理子、小嶋哲人：先天性血栓性素因の遺伝子解析の現状と展望　日本血栓止血学会誌　23(5), 465-471, 2012

 

鈴木敦夫、小嶋哲人：プロテインS異常症・欠損症の遺伝子解析　臨床検査　55(4), 347-355, 2011.

 

宮田敏行、川崎富夫、坂田洋一、村田満、小嶋哲人：日本人の血栓性素因　特にプロテインS欠損症を中心に　日本産婦人科・新生児血液学会誌　20(2), 75-82, 2011.

 

鈴木敦夫、小嶋哲人：第IX因子の変異と血栓症　血液フロンティア20(6), 902- 905, 2010.

 

宮田敏行、岡田浩美、川崎富夫、辻肇、窓岩清治、坂田洋一、小嶋哲人、村田満、池田康夫：日本人の血栓性素因　臨床血液　50(5), 381-388, 2009.

 

奥村薫、小嶋哲人：特集・抗Xa薬療法　３．抗Xa凝固　−現状と展望−　血栓と循環　17(1), 34-37, 2009.

 

藤森祐多、小嶋哲人：VI. 凝固線溶系　5.抗凝固薬—最近の進歩　Annual Review 血液 2009　高久史麿ほか編　中外医学社 東京pp244-250, 2009.

 

奥村薫、小嶋哲人：I. 基礎　3.血友病の病態　3）血友病Bの分子病態　血友病の基礎と臨床　白幡聡編　医歯ジャーナル社 東京pp52-59, 2009.

 

柏木隆宏、国島伸治、今井利、山下淳、三田直美、藤森祐多、奥村薫、村手隆、高木明、小嶋哲人：GPIIIa遺伝子のスプライシング以上によりGPIIb/IIIaを欠如した血小板無力症　日本検査血液学会雑誌　8(2): 179-185, 2007.

 

奥村薫、小嶋哲人：臨床検査による血栓症の病態解析−凝固系：血栓症−血管障害に対応する医療　成人病と生活習慣病　36(12): 133-136, 2006.

 

岡田浩美、小嶋哲人：第4章　主要疾患：現況・病態・診断・治療 36．プロテインC，プロテインS欠乏症　「血液疾患」-state of arts Ver.3　別冊・医学のあゆみ　坂田洋一ほか編　p765-768, 医歯薬出版、2005.

 

山影望、小嶋哲人：第1章　病態生理に関する基礎的・臨床的研究：最近の進歩　■病態研究　72．第V，第VIII因子合併欠乏症の病因　「血液疾患」-state of arts Ver.3 別冊・医学のあゆみ　坂田洋一ほか編　p295-298、医歯薬出版、2005. 9.15.

 

高木明、小嶋哲人：特集・検査値を読む「凝固因子」　内科　93 (6), 1210-1213, 2003.

 

高木明、小嶋哲人：遺伝子改変動物から学ぶ血栓症　第１回「antithrombinとryudocanのノックアウトマウス」　血栓と循環　11 (4), 268-270, 2003.

 

小西得司、岩瀬三紀、柳田正光、永田浩三、小嶋哲人、乳原善文、大手信之、松本義也、池田修一、伊藤雅文：第99回日本内科学会講演会における「内科専門医によるCPC」−原因不明の出血を初発症状とし、心症状が進行性に出現し死亡した71歳男性−　内科専門医会誌　15 (1): 9-47, 2003.

 

中出祐介、山田貴之、太田明伸、高木明、村手隆、小嶋哲人：発現ベクターを用いた抗マウスアンチトロンビン抗体の作製　らぼ　53 (1): 17-22, 2002.

 

石黒和博、小嶋哲人、齋藤英彦：ジーンターゲティングを用いた血液凝固制御因子の生体における機能解明：マウスantithrombinの完全欠損による胎児死亡とsundecan-4欠損による胎盤迷路層胎児血管の変性　日本血栓止血学会誌　13 (1): 9-16, 2002.

 

石黒和博、小嶋哲人：凝固制御因子のノックアウトマウス　　「Annual Review 血液 2002」　高久史麿ほか編　p203-206,　中外医学社、2002.

 

中山享之、小嶋哲人：プロテインＳ欠乏症　血栓止血学会誌　12 (3):  235-239, 2001.

 

山田貴之、高木明、中出祐介、村手隆、柳田正光、中山享之、山本晃士、松下正、高松純樹、齋藤英彦、小嶋哲人：Long-PCR法を用いた血液凝固第VIII因子遺伝子の逆位解析　血栓止血学会誌　12 (3): 187-196, 2001.

 

高木明、小嶋哲人：血友病の家系内診断　Modern Physician 20 (7); 837-842, 2000.

 

高木明、小嶋哲人：1. 血液学の基礎知識  3) 凝固・線溶因子とその調節機構 e) 血管内皮の機能　検査と技術 28 (7); 661-662, 2000.